Muscle, neoplasm of, malignant (excluding soft tissue sarcoma)—100

Muscle, neoplasm of, malignant (excluding soft tissue sarcoma) 

Malignant neoplasm of muscle refers to the development of cancerous cells within the muscle tissue. This condition excludes soft tissue sarcoma, which is a separate category of malignant tumors originating from various soft tissues. Malignant muscle neoplasms can occur in different muscle groups throughout the body.

Causes and Risk Factors

Malignant neoplasm of muscle might be a result of the following:

• Genetic mutations or alterations in the DNA of muscle cells.
• Exposure to certain environmental factors or carcinogens.
• Family history of certain genetic syndromes associated with muscle cancer, such as Li-Fraumeni syndrome or neurofibromatosis.
• Previous radiation therapy to the affected area.
• Weakened immune system, such as in individuals with HIV/AIDS or undergoing immunosuppressive therapy.

Symptoms

Signs and symptoms include:

• Pain or tenderness in the affected muscle.
• Swelling or a palpable mass or lump.
• Muscle weakness or loss of function.
• Fatigue or unexplained weight loss.
• Night sweats.
• Fever or recurrent infections.
• Changes in the appearance of the overlying skin (e.g., discoloration, ulceration).

Diagnosis

Following tests and exams are performed to establish a definitive diagnosis of a potential malignant neoplasm originating from the muscle.

• Physical examination to evaluate symptoms and identify any palpable masses.
• Imaging tests, such as MRI, CT scan, or ultrasound, to visualize the tumor and assess its size, location, and involvement with nearby structures.
• Biopsy of the tumor for histopathological examination, which helps confirm the presence of cancerous cells and determine the type and grade of the tumor.
• Blood tests to assess overall health and identify any abnormalities that may be associated with the tumor.

Further diagnostic procedures may be required, such as PET scan or bone scan, to determine the extent of the disease and check for potential metastasis. Staging of the tumor to determine the extent of its spread and guide treatment decisions.